Endocrine Abstracts

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...

Objective: To study the GLP-1 pattern of secretion after an oral glucose tolerance test (OGTT) in women in postpartum reassessment of previous gestational diabetes (GDM). To evaluate clinical and laboratory parameters that can influence GLP-1 secretion.Patients and methods: Forty-eight women with a history of GDM were assessed one year after childbirth determining clinical and analytical characteristics and OGTT with 75 g. We measured glucose, insulin an...

We presented the case of a 21 years old patient, derived from Primary Care to evaluate low testosterone levels (total testosterone (TT) 0.44 ng/ml). His father had delayed pubety and his mother menarche was at 11 years. No other personal history of interest. He had adequate child development and vaccination. No parotiditis. He referred some morning erections. Weight 59 kg, size 171 cm and BMI 20.17 kg/m2. Testes volume (TV) of 4-5 cc, scanty pubic hair. Tanner stage...

Introduction and objectives: Metformin (MTF) is the most used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). However, intolerance to drug is frequent and limits its use. There are controversies about the cause of this problem, the gut microbiota has been proposed to be responsible. The gradual introduction of MTF could exercise an adaptation of gut microbiota that would facilitate tolerance to MTF. In this study we evaluate the metabolic changes and gut mic...

Introduction: A multidisciplinary clinic has been developed to optimize the diagnosis and treatment of bone metabolism diseases. Initiated in March 2013, it is carried out simultaneously, once a week by an Endocrinologist and a Rheumatologist.Objective: To describe the experience of this unit in the last 12 months.Material and methods: Cross-sectional observational study. 235 patients were attended from December 2015 to December 20...

Introduction: 25-hydroxyvitamin D (25(OH)D3) deficiency has been associated with diabetes and obesity. However, the mechanisms underlying these relationships are not completely understood. Vitamin D receptor (VDR) is expressed in adipose tissue; it has been reported a higher expression in obese patients than in lean subjects, suggesting a differential vitamin D dynamics in adipose tissue according to the obesity degree. In addition, 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) is a...

Introduction: Somatostatin analogs (SS-analogs) are the treatment option when there is a persistent disease despite surgical intervention. They can be also recommended as a first line treatment if surgery is not appropriate (non-curative or contraindicated surgery).Objetive: To evaluate the effect of first-generation SS-analogs (lanreotide and octreotide) on tumour shrinkage and biochemical control in naive patients.Methods: We per...

An 18-years-old woman without medical history was referred for study of hypertension and an adrenal incidentaloma. The family history was significant for essential well-controlled hypertension in her father; diagnosed at 39 years-old. The patient complained of headache, asthenia, edema in lower limbs, high blood pressure values (200/150 mmHg) for one year (well controlled with losartan 100 mg/12 h, amlodipine 10 mg/24 h and doxazosin 4 mg/24 h) and marked facial acne previous ...

Blackground: Parathyroid carcinoma is a malignant neoplasm affecting 0.5 to 5.0% of all patients suffering from primary hyperparathyroidism. This cancer continues to cause challenges for diagnosis and treatment because of its rarity, overlapping features with benign parathyroid disease.Case report: 50 years-old-woman, without relevant previous history. She begins to present asthenia, weakness of lower limbs, arthralgias, cramps and appearance of a painfu...

Introduction: Glycogenosis is a group of hereditary diseases affecting the glycogen metabolism, due to mutations in enzymes involved in the transformation and synthesis of glucose (liver and muscle glycogenosis). Brain germ tumors are very infrequent. They are located mainly in pineal and sellar region. Central diabetes insipidus is the most frequent manifestation. Their prognosis and response to combined chemo/radiotherapy treatment are favorable.Case r...